The Human Vomeronasal (Jacobson's) Organ: A Short Review of Current Conceptions, With an English Translation of Potiquet's Original Text.

Stoyanov GS, Matev BK, Valchanov P, Sapundzhiev N, Young JR. The Human Vomeronasal (Jacobson's) Organ: A Short Review of Current Conceptions, With an English Translation of Potiquet's Original Text. Cureus. 2018 May 17;10(5):e2643. doi: 10.7759/cureus.2643. PMID: 30034965; PMCID: PMC6050168. Abstract The vomeronasal organ (VNO) is a structure located in the anteroinferior portion of the nasal septum and is part of the accessory olfactory system. The VNO, together with its associated structures, has been shown to play a role in the formation of social and sexual behavior in animals, thanks to its pheromone receptor cells and the stimulating effect on the secretion of gonadotropin-releasing hormone. The VNO was first described as a structure by the Dutch botanist and anatomist Frederik Ruysch in 1703 while dissecting a young male cadaver. This finding, however, is widely contradicted due to no elaborate descriptions being made by the Ruysch. The description of the VNO is more widely attributed to the Danish surgeon Ludwig Jacobson, with whom the VNO has been synonymized, as in 1803 he described the structure in a variety of mammals. Whilst Jacobson extensively studied prior reports of the VNO, he publicly denied its existence in humans. Following these discoveries and some contradictory statements in 1891, M. Potiquet published one of the more influential reviews on the topic. To this day, despite the first report of the organ's existence being made in a human and many articles stating its presence and supporting its function, the presence of a VNO in humans is still widely debated upon.